p-Toluenesulfonic acid

p-Toluenesulfonic acid - Names and Identifiers

Name	p-Toluenesulfonic Acid
Synonyms	TL65 TL65LS PTSA 70 PTS ACID Tosic acid toluene-4-sulphonic Toluene-p-sulfonate p-tolylsulfonicacid Toluenesulfonic acid p-Toluenesulfonic Acid P-Toluene Sulfonic Acid ParaTolune Sulfonic Acid P-Toluene Sulphonic Acid para toluene sulfonic acid PARATOLUENE SULPHONIC ACID Methylbenzenesulfonic acid para toluene sulphonic acid 4-methylbenzenesulfonic acid
CAS	104-15-4
EINECS	203-180-0
InChI	InChI=1/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)

p-Toluenesulfonic acid - Physico-chemical Properties

Molecular Formula	C7H8O3S
Molar Mass	172.2
Density	1.07
Melting Point	106~107℃
Boling Point	116 °C
Flash Point	41 °C
Water Solubility	soluble
Vapor Presure	69.8Pa at 20℃
Appearance	Solution
Color	Clear colorless to light yellow
pKa	-0.43±0.50(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.3825-1.3845
Physical and Chemical Properties	Characteristics colorless monoclinic plate or columnar crystals. melting point 106~107 ℃ boiling point 140 ℃ solubility: soluble in ethanol and ether, slightly soluble in water and hot benzene.
Use	Used in pharmaceuticals, pesticides, dyes and detergents, also used in plastics and printing coatings

p-Toluenesulfonic acid - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R34 - Causes burns R10 - Flammable
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S23 - Do not breathe vapour.
UN IDs	2585
HS Code	29163990
Hazard Class	8
Packing Group	III

p-Toluenesulfonic acid - Upstream Downstream Industry

Raw Materials	Methyl alcohol Sulfuric acid
Downstream Products	dodecyl benzenesulfonic acid, sodium salt

p-Toluenesulfonic acid - Nature

Open Data Verified Data

colorless monoclinic plate-like or columnar crystals, flammable. Soluble in ethanol and ether, slightly soluble in water and hot benzene. Sometimes with one or four crystal water. The melting point of the anhydrate was 106-107 °c. Boiling Point (2. 67kPa) 140 ℃.

Last Update：2024-01-02 23:10:35

p-Toluenesulfonic acid - Preparation Method

Open Data Verified Data

prepared by sulfonation using toluene as a raw material and heating and boiling with sulfuric acid. The mother liquor of the production process contains uncrystallized methyl benzene sulfonic acid and free sulfuric acid. After neutralization, sodium methylbenzenesulfonate can be produced.

Last Update：2022-01-01 10:55:23

p-Toluenesulfonic acid - Use

Open Data Verified Data

used in the preparation of cresol and Pharmaceutical (such as the preparation of doxycycline), pesticides (such as the preparation of dicofol), dyes and detergents and other industries. It is also used in the plastics and printing coatings industry.

Last Update：2022-01-01 10:55:23

p-Toluenesulfonic acid - Safety

Open Data Verified Data

the use of plastic bags plus wooden boxes packaging, storage in a cool, ventilated, dry place. According to the provisions of the storage and transportation of toxic chemicals.

Last Update：2022-01-01 10:55:24

p-Toluenesulfonic acid - Reference Information

LogP	0.41 at 25℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Overview	p-toluenesulfonic acid (Molecular Structure: p-CH3C6H4SO3H, also written in TsOH, English P-Toluene Sulfonic acid) abbreviated PTS, is a non-oxidizing organic strong acid, white needle-like or powder-like crystals, soluble in water, alcohols, ethers and other polar solvents. Easy deliquescence, easy to make wood, cotton fabric dehydration and carbonization, difficult to dissolve in benzene and toluene. P-cresol is generated during alkali fusion. Common is p-toluenesulfonic acid monohydrate (TsOH. H2O) or tetrahydrate (TsOH. 4H2O). P-toluenesulfonic acid is industrially prepared by sulfonating toluene with concentrated sulfuric acid. The obtained P-toluenesulfonic acid often contains benzene sulfonic acid and sulfuric acid impurities, which can be purified by recrystallizing the impure sample in concentrated hydrochloric acid and then azeotropic drying. P-toluenesulfonic acid is widely used in the synthesis of pharmaceuticals, pesticides, polymerization stabilizers and Organic Synthesis (esters, etc.) of the catalyst, coating intermediates and resin curing agents. It is a commonly used acid catalyst in organic synthesis. With it and sodium hydroxide neutralization of p-Toluenesulfonyl sodium sulfonate, and phosphorus pentachloride, P-Toluenesulfonyl chloride can be prepared. The latter is used in nucleophilic substitution reactions and also as a protecting group for the hydroxyl group of the alcohol. p-CH3C6H4SO3Na PCl5 → p-CH3C6H4SO2Cl p-toluenesulfonic acid also catalyzes the use of dihydrofuran protecting groups on alcohols, esterification of carboxylic acids, transesterification, acetal formation of aldehydes, etc.
reference quality standard	project/index industrial grade pharmaceutical grade refined reagent grade (chemically pure) content (using C7H8O3S · H2O) calculated ≥ 90-93.096.097.098.0 free acid (H2SO4) ≤%3.00.70.50.1 water (excluding crystal water) ≤% 4.52.3/51.5 iron (based on Fe ++) ≤ ppm50303010 burning residue ≤%/0.20.20.02 melting point (°C)/102-105 ethanol dissolution test/qualified and qualified water dissolution test/qualified and qualified
Use	used as a chemical reagent, also used in dyes, organic synthesis used in medicine (such as doxycycline), pesticides (such as Dicofol), dyes and other intermediates. Also used in detergents, plastics, coatings and other aspects. used in pharmaceuticals, pesticides, dyes and detergents, also used in plastics and printing coatings widely used in the synthesis of pharmaceuticals, pesticides, polymerization stabilizers and Organic Synthesis (esters, etc.) the catalyst. It is also used as an intermediate for medicine, coating and curing agent for resin.
production method	obtained by hydrolysis of p-Toluenesulfonyl chloride. Toluene can also be used as a raw material and obtained by sulfonation with sulfuric acid.
category	corrosive article
toxicity grade	low toxicity
Acute toxicity	oral-rat LD50: 2480 mg/kg
flammability hazard characteristics	flammable; Toxic sulfur oxide gas emitted from the fire
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; Stored separately from alkali
fire extinguishing agent	water mist, carbon dioxide, foam
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-10 22:29:15

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p-Toluenesulfonic acid

Raw Materials for p-Toluenesulfonic acid

Methyl alcohol
Sulfuric acid

Downstream Products for p-Toluenesulfonic acid

dodecyl benzenesulfonic acid, sodium salt

p-Toluenesulfonic acid

p-Toluenesulfonic Acid

CAS: 104-15-4

Molecular Formula: C7H8O3S

p-Toluenesulfonic acid - Names and Identifiers

p-Toluenesulfonic acid - Physico-chemical Properties

p-Toluenesulfonic acid - Risk and Safety

p-Toluenesulfonic acid - Upstream Downstream Industry

p-Toluenesulfonic acid - Nature

Open Data Verified Data

p-Toluenesulfonic acid - Preparation Method

Open Data Verified Data

p-Toluenesulfonic acid - Use

Open Data Verified Data

p-Toluenesulfonic acid - Safety

Open Data Verified Data

p-Toluenesulfonic acid - Reference Information

Supplier List

p-Toluenesulfonic acid Request for Quotation

p-Toluenesulfonic Acid

CAS: 104-15-4

Molecular Formula: C7H8O3S

p-Toluenesulfonic acid - Names and Identifiers

p-Toluenesulfonic acid - Physico-chemical Properties

p-Toluenesulfonic acid - Risk and Safety

p-Toluenesulfonic acid - Upstream Downstream Industry

p-Toluenesulfonic acid - Nature

Open Data Verified Data

p-Toluenesulfonic acid - Preparation Method

Open Data Verified Data

p-Toluenesulfonic acid - Use

Open Data Verified Data

p-Toluenesulfonic acid - Safety

Open Data Verified Data

p-Toluenesulfonic acid - Reference Information

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p-Toluenesulfonic acid